Effect of Vitamin D on Lipid Profile and Oxidative Stress in Rheumatoid Arthritis Patients

Abstract

The current study was designed to investigate the level of vitamin D and its relationship with some biochemical parameters of rheumatoid arthritis patients in Thi Qar Governorate / Iraq. The study targeted 100 women diagnosed with rheumatoid arthritis, and their ages ranged between 30-80 years. As well as 50 healthy women of the same age as a control group, during the period from November 2020 to July 2021. Blood samples were used to obtain serum, which was used to measure biochemical tests, including Vitamin D (Vt. D), Lipid Profile, Oxidant-antioxidant system. The results showed a significant increase (p≤ 0.05) in the level of body mass index accompanied by a significant decrease (p≤ 0.05) in Vitamin D level in patients with rheumatoid arthritis compared to the control group. Also, The results showed that, the differences Vitamin D levels were not significant (P>0.05) when comparison of patients based on body mass index BMI.

Regarding the lipid profile, our results showed the presence of a significant increase (p≤ 0.05) in concentration of the cholesterol CHO, triglycerides TG, low-density lipoprotein LDL and very low-density lipoprotein VLDL, On the other hand, a significant decrease (p≤ 0.05) in the concentration of high-density lipoprotein HDL in the patients compared to the control group. On the other hand, patients within the third group for BMI showed a significant increase (p≤ 0.05) in all parameters of the lipid profile, except for HDL, which decreased significantly (p≤ 0.05) compared with the first group for BMI. As for the oxidant-antioxidant system, the results showed that there was a significant increase (p≤ 0.05) in MDA and ceruloplasmin concentration. While the albumin concentration was significantly lower for patients compared to the control group. When comparing based on BMI, despite the positive relationship between MDA and BMI, However, the difference in MDA value was not significant (P>0.05) among the three BMI groups for patients. In addition, albumin and ceruloplasmin did not record any significant differences (P>0.05) among patients.