Evaluation the effect of (-)-epigallocatechin (EGC) on ETV6-NTRK3 fusion gene harboring cell lines

Abstract

(-)-epigallocatechin (EGC) is one of the most important compounds that play a crucial on forming the biological activity of tea. There have been reports on the cytotoxic effect of EGC on certain types of cancer as well as its molecular mechanism; however, EGCG, another derivative of EGC, has been the most studied tea object. The toxicity of EGC was investigated in this study on AML cell lines containing the ETV6–NTRK3 fusion gene. The results revealed that EGC had a significant inhibitory effect on the ALM cell lines with the IC₅₀ values of were 11.39 ± 0.99 mM for Ba/F3-AML; 14.42 ± 0.95 mM  for Ba/F3-CFS; 21.49 ± 0.98 mM for MO-91 and 20.90 ± 1.52 mM for IMS-M2.