In vivo Anti-inflammatory and analgesic potential of root extract of Vetiveria zizanoides

Authors

  • Ajay Kumar, Amandeep Singh Baghla

Abstract

Objective: “This study objective was to determine the anti-inflammatory and analgesic effects of different ethanolic extracts of Vetiveria zizanioides root utilizing carrageenan-induced paw oedema and histamine-induced paw oedema.” Methods: For analgesic action, the hot plate and the acetic acid-induced writhing techniques are applied. After extraction of Vetiveria zizanioides root in ethanol at i100 mg/kg and 200 mg/kg, it demonstrated substantial anti-inflammatory and analgesic activity. At all dosages tested, ethanolic extracts substantially reduced carrageenan-induced inflammation. The extract prevented tearing in the writhing test caused by acetic acid, equivalent to the reference medication Diclofenac (10 mg/kg), which is statistically significant (p<0.05). “The extract dosage generated 100 to 200mg/kg of central analgesic activity when the hot plate technique was used. The hot plate test was utilized to determine peripheral action revealed that the extract at 100 and 200 mg/kg doses inhibited writhing in a manner comparable to the reference medication Diclofenac (10mg/kg), which is statistically significant (p<0.05).” Result: The extract dosage generated 100 to 200mg/kg of central analgesic activity when the hot plate technique was used. Thus, the results confirm the plant's historical usage in inflammatory diseases. However, further research should be undertaken to discover the accurate mechanism(s), to isolate the anti-inflammatory effect of the bioactive principle(s), and others. The present study examined theianalgesic and anti-inflammatory effects of an alcoholic extract of the Vetiveria zizanioides plant. The extraction was screened for flavonoids, tannin, saponin, and glycosides. In contrast, the acute toxicity research determined that a relative Ld-50 of 2000mg/kg oral (according to OECD guideline 423). Conclusion: The extract exhibited analgesic action on both the central and peripheral nervous systems

Published

2021-09-01 — Updated on 2021-09-13

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How to Cite

Ajay Kumar, Amandeep Singh Baghla. (2021). In vivo Anti-inflammatory and analgesic potential of root extract of Vetiveria zizanoides. Drugs and Cell Therapies in Hematology, 10(1), 1639–1650. Retrieved from http://dcth.org/index.php/journal/article/view/318 (Original work published September 1, 2021)

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Articles