Comparative Evaluation of Efficacy of PRF and Induced Bleeding in Regenerative Endodontic Therapy of Non-Vital Young Permanent Teeth- An in Vivo Study

Abstract

Introduction: Due to draw back of conventional apexification procedure a regenerative endodontics is gaining importance, which allows maturogenesis of developing root

Aim: To evaluate and compare the efficacy of PRF with that of induced bleeding in revascularization of the non-vital immature permanent teeth 

Materials and Methods: Thirty healthy pediatric patients of age 8-13yrs, with non-vital immature single rooted permanent teeth were selected amongst the patients. Patients were divided into two groups- Group A–15 patients were treated with induced bleeding technique (control group). Group B – 15 patients were treated with PRF membrane. Baseline radiographs were taken using CBCT and Radiovisiography (RVG) with paralleling technique and the extent of periapical radiolucency. The patient was recalled for follow up after 18 months for the clinical evaluation of signs and symptoms, and radiographic assessment of root maturogenesis. The outcome was categorized based on single or more increments in root length, dentin thickness, and decrease in width of apical foramen, decrease in periapical radiolucency on CBCT images.

Results: It was observed that periapical lesion was healed significantly as well as closure of apical foramen was obtained post operatively. Root length was significantly increased in PRF group (13.73%) as compared to Induced bleeding group (8.61%) however, dentin thickness increased more in induced bleeding group (37.16%).

Conclusion:The present study showed that the PRF is more effective than blood clot for regenerative endodontic therapy of non-vital immature permanent teeth.