Gastro Protective Effect of Ethanolic Extract of Anchusastrigosa on Indomethacin-Induced Gastric Ulcer in Rats

Abstract

The use of long-term non-steroid anti-inflammatory drugs is one of the most common causes of gastric ulcer, which occurs and spreads all over the world (NSAIDs). Anchusa strigosa   which has  gastroprotective effect due to antioxidant and antiinflammatory compounds in its extract, as well as flavonoids such as, which act as antioxidants and other bio active compounds. The purpose of this study was to see howAnchusa strigosa extract affected on ulcer index and PH of stomach and on the expression of SOD-1 and TNFα in indomethacin-induced gastric ulcers. In this 30 healthy male albino rats were divided into five groups (N=6). A single oral dose of indomethacin (60 mg/kg body weight) was used to cause ulceration. The vehicle was given to the first group, while indomethacin was given to the second. The third group pretreated omeprazole (the reference drug) at a dose of 20 mg/kg, while the fourth and fifth groups pretreated ethanolic crude at a dose of 500 mg/kg orally once daily for 21 days prior to ulcer induction.The results showed thatAnchusa strigosa extract significantly increased SOD expression as well as PH and decreased TNFα expression and ulcer index. Histopathology analysis revealed that the gastric epithelial improved following Anchusa strigosaadministration. These findings show that plant extract, through its antioxidant and anti-inflammatory properties, can protect indomethacin-induced gastric ulcer rats while also improving gastric histopathology.