A Brief Review on Ion Exchange Resign with Code of Federal Regulation

Authors

  • Vijay Sharma, Dr. Pankaj Arora, Laxmi Kant,

Abstract

Ion exchange resins have received considerable attention from pharmaceutical scientists because of their versatile properties as drug delivery. Research over the last few years has revealed that ion exchange resins are equally suitable for drug delivery technologies, including controlled release, transdermal, nasal, topical and taste masking. An ion exchange resin is a polymer (normally styrene) with electrically charged sites at which one ion may replace another. Natural soils contain solids with charged sites that exchange ions, and certain minerals called zeolites are quite good exchangers. The major drawback of controlled release is dose dumping, resulting in increased risk of toxicity. The usage of IER during the development of controlled release formulations plays a significant role because of their drug retarding properties and prevention of dose dumping. The important step in the preparation of drug resinates is to purify the resins. Purification of resin can be achieved by washing with absolute ethanol, ethanol and water mixture. Final washing with water removes all the impurities. The mechanism of binding of drug to IER involves the electrostatic interactions between the resins and oppositely charges drugs and also the hydrophobic interaction as shown. The driving force behind this exchange is due to the electronic differences between the ions. The drug resinates are noncrystalline, usually spherical in shape and hydrate readily upon immersion in an aqueous medium. They are considered as safe materials due to their insoluble and nonabsorbable nature. Particle size of ion exchange resins can strongly influence the release or dissolution behavior of the drug from drug–resinates, thus the potential applications. The FDA has the responsibility to define conditions under which safe food additives may be used in the production and preparation of foods and beverages. These conditions are written in the Code of Federal Regulation (CFR), title 21, part 173 (secondary direct food additives permitted in food for human consumption). Ion exchange is an ancient technique documented more than hundred years ago. Since then they were used for softening water to an incomparable wider scale of applications and has become an integral part of new technical and industrial processes.

Published

2021-10-01

How to Cite

Vijay Sharma, Dr. Pankaj Arora, Laxmi Kant,. (2021). A Brief Review on Ion Exchange Resign with Code of Federal Regulation. Drugs and Cell Therapies in Hematology, 10(1), 204–211. Retrieved from http://dcth.org/index.php/journal/article/view/523

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Articles