Fabrication and Characterization of Famotidine Solid Lipid Nanoparticles Using Hot Emulsification Method for Bioavailability Enhancement

Abstract

Objectives: The objective of this paper was to fabricate and increase the effectiveness of the formulation of solid lipid nanoparticle (SLN) on improving the oral bioavailability of famotidine. Methods: In this study, ultrasonic-hot emulsification technology was used to manufacture famotidine-SLN. Subsequently, the particle diameter, electrokinetic potential, and Encapsulation Efficiency of SLN were all determined during the characterization process. The bioavailability of famotidine with 40 mg/kg BW was evaluated to male Wistar rat orally. Results: The results showed that the mean particle size of SLN containing famotidine was prepared on average 151,90 ± 26,05 nm and a relatively small size distribution (0,35 ± 0,04). Famotidine- SLN had a high entrapment efficiency in average 82,30 ± 4,39 %. Famotidine-SLN showed a 3.5-fold increase in C_max and a 4.3-fold increase in AUC0 than free famotidine (suspension). Conclusions: SLN improved oral bioavailability of famotidine significantly compared with famotidine suspension. SLNs seem to offer a potential delivery strategy to increase the solubility and bioavailability and permeable medicines.