Evaluation of Nerve Growth Factor, Fetuin A and Adiponectin Levels in Diabetic Patients with Sensory Neuropathy

Abstract

Background:  neuropathy is a common complication in patients with diabetes that occurs as a result of hyperglycemia for a long period of disease. Neuropathy is one of the most disabling severe comorbidities. Accordingly, biochemical parameters have importance to apply as good predictor factors.  Therefore, this study seeks to assess the levels of nerve growth factor, fetuin A, adiponectin, and HbA1C to knowledge the extent of them employed as early predictors of disease and study their correlation.

Methods: Ninety persons were included in this study, aged range (40-75) years old. They classified into three groups. First group is consisting of 30 patients whom suffering from diabetes with nerves disorders. Second group consists of 30 patients without neuropathy. Third group collected of 30 healthy persons that representing the control group. Factor levels that used in this study were measured by ELISA method, HbA1c was determined using ichroma device.

Results: the results revealed that the level HbA1C possesses a significant increase in patients than its level in control. In contrast, NGF level was decreased significantly, in the case of patients than healthy subjects.  Fetuin A results showed a high level in the case of patients than control group, while adiponectin showed no significant differences between patient and healthy groups, in males. Whereas female results revealed that adiponectin level possesses considerable differences among patient and control groups. In contrast, NGF level decreased in patients than healthy subjects. Inversely, fetuin A level in DPN group was found to be higher than its level in control and diabetic without neuropathy groups. ROC curve data referred to that NGF and HbAIC represent strongest markers in females. Whereas, the perfect markers of males are including both fetuin A and HbAIC.

Conclusion

According to the results of the current study, levels of the studied factors consider good indicators, which represent suitable early detectors for early detection of patients with diabetic nephropathy. Analysis data of ROC curve revealed that NGF and HbA1C is the perfect markers in females. In contrast, fetuin A is found to be a better factor for detection of disease in males.